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OS also activates NF-B and Cezanne to further promote HIF-1 transcription and stabilization, which in turn enhances the glycolytic capacity through upregulating glycolysis regulators and enzymes (PFKFB3, HK2, and enolase), driving EC proliferation and inflammation [221]
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N-Acetyl Cysteine (NAC) NAC is not glutathione itself but is the most well-established precursor for raising intracellular glutathione levels
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