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to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction or non-fatal stroke) in adults with type 2 diabetes and established cardiovascular disease

Luger et al

The Nissen and Toupet fundoplication are surgical procedures in which the upper part of the stomach (fundus) is wrapped around the lower part of the esophagus to reinforce the reflux valve

For instance, PDE4 inhibitors such as roflumilast, used in COPD, frequently induce gastrointestinal and CNS-related side effects, including diarrhea, nausea, headache, insomnia, and weight loss (Janjua et al., 2020

The potential relevance extends beyond weight loss