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Their characterization by electrophysiological approaches revealed that they are mostly closed under basal conditions and activated by different stimuli that are also known to induce eryptosis: ROS, exposure to high extracellular osmolarity, or removal of extracellular Cl - and isosmotic replacement with gluconate activate the channel [98] and trigger eryptosis [90]

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doi: 10.1007/S12011-020-02077-Z 75

Furthermore, CerS6 was found to have a detrimental effect on mitochondrial dynamics and function, while increasing apoptosis in neuronal cell culture