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We have previously shown expression of P2X3 receptor (which is activated by ATP) in enteric neurons of the submucous plexus in the normal human gut, with an increase in patients with active CD [47]
Treatments with methylprednisolone, thalidomide, hydroxychloroquine drugs or sympathetic blockages (stellate ganglion block) were unable to effectively improve the symptoms
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Yin HZ, Sensi SL, Ogoshi F, Weiss JH
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