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The starting dose matters enormously for tolerability

Within sensible limits, the basics help your body hold its levels: a diet that includes B12 sources if you are not vegan, limiting heavy alcohol use, and not smoking, since both affect how you absorb and store nutrients

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Rather, they fail within a complex, multicellular environment in which astrocytes, microglia, oligodendrocytes, vascular elements, and systemic immune components actively participate