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Furthermore, BHB influences adipocytes by upregulating uncoupling protein 1 (UCP1) and PR domain containing 16 (PRDM16) via the AMP-activated protein kinase(AMPK)/SIRT1/PGC-1 pathway, resulting in reductions in body weight and lipid levels [112]
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In the liver, it upregulates KLF4, activating detox cascades and supporting hepatic stem cell turnover
The first human safety study on health volunteers was conducted in 2002 and a phase 2 double blind, randomized clinical trial (small and not sufficient for US phase 2 purposes) was conducted in 2005 with BPC-157 enemas for ulcerative colitis, with some promising effects (see research name PL 14736 to find the references)
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