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Anecdotal evidence and pharmacoepidemiological studies in humans report reduced alcohol use by patients using GLP-1RAs for other indications

Elevated superoxide generated from dysfunctional mitochondria promotes the formation of excessive H 2 O 2 , the substrate for MPO-mediated hypochlorous acid synthesis and the generation of the inflammatory biomarker, 3-CT

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and JP23H04921 to Ya.S), AMED-CREST (grant number 24gm1410007h0004 to F.O.), the Takeda Science Foundation (to F.O.), the Naito Foundation (to F.O.), AMED-PRIME (grant number JP21gm6410012 to A.E.), the MEXT Leading Initiative for Excellent Young Researchers (to Yu.S.), Tottori University Research Support Project for the Next Generation (to Yu.S.), and the Grant for International Joint Research Project of the Institute of Medical Science, the University of Tokyo (to Ya.S