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Overall, no increased risk of pancreatitis, pancreatic/hepatocellular/colorectal cancer, aspiration/pneumonia, or diabetic retinopathy is seen in patients on GLP-1 receptor agonist therapies
For someone carrying 50 excess pounds, losing 30 pounds decreases knee joint stress by 120 poundsa clinically meaningful reduction that directly improves mobility and decreases pain signals from cartilage
Furthermore, our analysis identified several potentially novel safety signals that warrant further investigation: Acute kidney injury (n = 675
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Going forward this provides a valuable yardstick for evaluating the benefits of GLP-1 drugs which have been used since 2005
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