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The relatively short half-life, compared with longer-acting compounds in the broader GH-axis class, is part of why Ipamorelin produces a pulsatile, physiologically patterned GH release rather than a sustained elevation, which is one of the reasons it remains a preferred reference tool for studying pulsatile GH secretion patterns

Stimulatory signals: GHRH from hypothalamus (primary stimulator), ghrelin from stomach, deep sleep, exercise, fasting/low blood glucose, certain amino acids

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Vella et al., 2000), GLP-1 receptor agonists (GLP1-RAs) have been widely used in clinic