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doi: 10.3390/ph19030463

The injectable form is used in research settings for systemic delivery, which may provide broader effects beyond the skin including potential benefits for hair growth (it has been shown to enlarge hair follicles and stimulate growth), lung tissue repair (COPD research), and neuroprotection

308,309 EMT, CSCs, and DTPs are interconnected via regulatory networks involving transcription factors (e.g., SNAIL, ZEB1), 318 signaling cascades (e.g., TGF-), and cues from the TME (e.g., CAFs, hypoxia), collectively sustaining tumor heterogeneity and adaptive resistance

These findings highlight the critical role of stromal-tumor interactions and suggest that targeting miR-432-5p or restoring CHAC1 function could represent promising strategies to overcome chemotherapy resistance in prostate cancer (Zhao et al., 2024)

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