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338 Too much open-mouth breathing during sleep can lead to drying of mouth and throat, periodontal disease and cavities, snoring, poor sleep, and onset and worsening of sleep apnea

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The absorption rate through sublingual tissue may differ significantly from subcutaneous injection, which could affect both the timing and magnitude of therapeutic effects

Taken together, these results suggest that CPP-CAND inhibited the FOXO4-p53 interaction in the nucleus, which enabled the extranuclear transport of p53 and selectively induced apoptosis in senescent cells