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GSH exists in both a reduced (GSH) and oxidized form, but most of it remains in the former
Overproduction of ROS can be caused by mitochondrial malfunction or unchecked SOD2 expression, which in turn can irreparably damage chondrocytes and trigger cell death via apoptosis or necrosis (Lepetsos and Papavassiliou, 2016)
While uric acid has antioxidant properties, excessive levels can lead to health issues such as gout and kidney stones
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