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Why they matter: Large randomised cardiovascular and renal outcome trials (EMPA-REG OUTCOME, DAPA-HF, DAPA-CKD, EMPEROR-Reduced/Preserved, CREDENCE, EMPA-KIDNEY) consistently showed reductions in heart-failure hospitalisation, progression of chronic kidney disease, and cardiovascular death
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Fat freezing is most effective for individuals with pinchable, distinct pockets of subcutaneous fat that resist regular diet and exercise
Canyelles M, Tondo M, Ced L, Farrs M, Escol-Gil JC, Blanco-Vaca F
Hypoxia stimulates neural stem cell proliferation by increasing HIF-1 expression and activating Wnt/-catenin signaling
These studies also indicate that daily consumption of l-carnitine, even while maintaining a vegan/vegetarian diet, can induce the gut microbiotadependent BBTMA transformation, resulting in heightened formation of the atherogenic and prothrombotic metabolite TMAO
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