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Because of that extra mechanism, early research shows that retatrutide may lead to greater fat loss and appetite suppression compared to tirzepatide

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Common side effects include: Nausea and vomiting Digestive issues like diarrhoea, constipation, or abdominal pain Headaches and fatigue Injection site reactions Serious but less common side effects: Pancreatitis Gallbladder problems Kidney problems Low blood sugar Most gastrointestinal side effects settle within the first month or two

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