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Genentech, Roche) for adult patients with active lupus nephritis who are receiving standard therapy, marking the first anti-CD20 monoclonal antibody approved for this serious kidney complication of systemic lupus erythematosus

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The mechanism of action involves several physiological effects: GLP-1 receptor agonists stimulate insulin secretion in a glucose-dependent manner, suppress glucagon release, slow gastric emptying, and reduce appetite through central nervous system pathways

Vaubourdolle, M, et al., Clinical Chemistry 41: 1716-1719, 1995 2

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