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Mutations in ELAC2 associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3-end processing

Lau IP, Chen H, Wang J, Ong HC, Leung KC, Ho HP, et al

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In 2019, Kolchina, Khavinson, and colleagues used molecular docking and molecular dynamics simulations, published in Nucleic Acids Research , to systematically analyze how dipeptides could bind tetranucleotide sites within double-stranded B-form DNA, and identified structural motifs consistent with sequence-selective binding