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Appendicitis did not increase risk of CC: MRC-IEU(OR:1.000, 95%CI:0.999-1.001, P=0.641), Neale lab(OR:1.000, 95%CI:1.000-1.001, P=0.319)

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As all major obesity guidelines emphasize, lifestyle-based behavioral therapy remains the first-line foundation of care, with pharmacotherapy used as an adjunct rather than a replacement [35,36,37]

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