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These findings underscore the crucial role of PCSK1 in energy homeostasis and endocrine regulation in humans ( SIM1 gene SIM1 gene mutations are responsible for rare forms of monogenic obesity ( SIM1 gene is responsible for encoding a transcription factor which is essential for neuronal development in the paraventricular nucleus of the hypothalamus, a brain region critical for the regulation of appetite and energy balance ( SIM1 transcription activity, leading to hypothalamic dysfunction, increased food intake, and, thus, severe obesity

Data from Cornell University shows that households using GLP-1 drugs reduced their grocery store spending by 5.3% and fast-food restaurant spending by 8%, with spending recovering after discontinuation

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Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F