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Following FOXO4 displacement, the released p53 undergoes nuclear export and mitochondrial translocation, activating the intrinsic apoptosis pathway via BAX upregulation and BCL-2 downregulation, culminating in caspase-3 cleavage and apoptotic cell death
Think of glutathione as a cellular bodyguard
Martinez B, Peplow PV
Reduced DHFR activity is relatively uncommon in European populations but considerably more prevalent in some Asian populations
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