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Liraglutide can enter specific brain regions associated with appetite regulation, electrophysiological measurements of mouse brain sections showed that GLP-1 directly stimulated promelanocortin (POMC)/cocaine and amphetamine regulated transcript (CART) neurons and indirectly inhibited neurotransmission of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in arcuate nucleus neurons through GABA-dependent signal transduction
M.SuschekC
IV supplementation helps maintain protective levels in patients with these conditions, supporting immune function and reducing the oxidative burden that accelerates disease progression
Nat Commun 15:2061
As shown in that report, combination treatment with metformin and liraglutide can ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway 25
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