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Psychiatry 68, 315326
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This mechanism has implications for the estimated 100 million Americans with fatty liver disease, many of whom have no effective pharmacological treatment options
The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)
3A) or the proportion of patients with PFO greater than or equal to 300 mmHg (44.1% vs
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