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Molecular Cell Biology, 22 (2), 119
Viruses, bacteria, heavy metal toxicity, radiation, certain medications, and even the normal process of aging can all cause free-radical damage to healthy cells and deplete Glutathione
When levels fall low enough, oxidative stress accumulates, which is associated with fatigue, compromised immune response, accelerated skin aging, and increased strain on the liver
Its mitochondrial origin and metabolic signaling role are well-documented in peer-reviewed literature