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Oxidative Medicine and Cellular Longevity, 2012 , 324832
Yet another small molecule that has been studied extensively as a highly potent small molecule inhibitor of both human and murine CD38 is 78c, which has been shown to be 10-fold less potent against the cyclase activity than the hydrolase activity of recombinant human CD38 139
This oxidized form is reversed by thioredoxin (Trx)/Trx reductase/NADPH system, although, in RBCs, it is a very slow regeneration due to the low concentrations of Trx reductase [73]
reported an incidence rate of approximately 14% in athletes, with recurrence rates as high as 45% in volleyball players and 32% in basketball players [3, 4]
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