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OPCs also have the ability to produce and release 2-AG themselves, indicating a potential autocrine and paracrine signaling mechanism that can further promote differentiation (Gomez et al., 2010, 2011)
L., de Cabo, R., & Cohen, P
Extended Data Figure 8 Effects of the PAM binding pocket mutations on potency of compound 2
doi: 10.1016/j.bbr.2019.02.031 77
Although, there are some of studies related to the treatment of T2DM by berberine in activating this signaling pathway in intestine cell, it is few study about the paracrine effect of GLP-1 in cell ( Conclusion In conclusion, we confirmed in vivo that berberine has the effect of treating T2DM and enhancing the function of islet cell, and then showed that this effect is produced by activating the GLP-1/GLP-1R/PKA signal pathway in the intestine and islet
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