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Liu MY, Yin CY, Zhu LJ, Zhu XH, Xu C, Luo CX, et al

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GH and IGF-1 levels gradually return to baseline, and any enhanced benefitslike improved recovery or body compositionmay diminish over time

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Several small clinical trials and mechanistic studies suggest berberine may improve insulin sensitivity, reduce fasting glucose, and modestly lower lipid levels, though effect sizes are typically smaller than those observed with prescription medications