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The therapeutic potential of cystathionine beta-synthetase/hydrogen sulfide inhibition in cancer
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Methods The current study involves the fusion of a native or mutant GLP-1 (30 residues) with an HSA-binding DARPin (123 residues) via a rigid helical linker (15 residues) to create fusion proteins (168 residues) resistant to DPP-IV and, or trypsin with extended half-lives using structural modeling, which are subsequently characterized using MD simulation and molecular docking analyses
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10.1046/j.1365-313X.2002.01391.x Plant J
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