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The REWIND trial for dulaglutide showed a 12% reduction in major cardiovascular events (heart attack, stroke, or cardiovascular death) over a median of 5.4 years
This means that, overall, tirzepatide is a more effective medication, but can cause more severe side effects, possibly to it being more potent due to its dual-action mechanism
For many patients, digestive side effects like heartburn and nausea are most intense during the first few weeks of treatment or after a dosage increase
Adverse Reactions (6.2).] 5
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