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What this means for patients Let us be clear about what this does and does not mean
No dose adjustment is required for renal impairment, but monitoring is advisable in patients with CKD experiencing severe gastrointestinal symptoms
REDEFINE-1 showed that adding amylin to a GLP-1 backbone improves results
Lipoatrophy, the opposite condition where fat tissue breaks down and leaves indentations in the skin, can also occur with repeated injection in the same spot
Many users on tirzepatide drastically reduce their sodium intake simply because they are eating less, and this contributes to the electrolyte imbalance
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![PDF] Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation (](https://figures.semanticscholar.org/3eda016f489dc2a1889c3a5f963c636f9c9d8e5d/2-Figure1-1.png)
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