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The third body is in vivo rodent work, largely on muscle, bone, gut and neural tissue, some of it using the LR3 variant specifically because its altered clearance and reduced binding-protein capture change tissue exposure relative to native protein
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In a 4-year CV outcomes trial (Trial 7), 4,825 patients were randomized to semaglutide tablets for a median follow-up of 49.6 months and 4,825 patients were randomized to placebo for a median follow-up of 49.4 months [see Clinical Studies (14.4)]
EMBO J (2003) 22(23):626776.10.1093/emboj/cdg599 46 VeverkaVHenryAJSlocombePMVentomAMulloyBMuskettFWet alCharacterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation
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