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10.1016/S0899-9007(98)80041-5 Capdevila JH, Morrow JD, Belosludtsev YY, Beauchamp DR, DuBois RN, Falck JR: The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s)
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Consistent with reports in other cancer types showing that GPX2 overexpression promotes cisplatin resistance by suppressing ROS accumulation, our findings suggest that NAC-associated upregulation of GPX2 may enhance intracellular antioxidant defenses, thereby promoting survival of residual tumor cells and contributing to chemoresistance [21, 22]
Symptoms include shakiness, sweating, confusion, dizziness, and rapid heartbeat
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