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A- Methylcobalamin is the active form of vitamin B12 with better nerve affinity and retention, while cyanocobalamin is synthetic and requires conversion in the body
A patient arrives having heard about Wegovy or Mounjaro perhaps from a news article, perhaps from a friend who has lost significant weight, and the discussion centres almost entirely on efficacy and tolerability
He sees an expanding clinical role for these drugs and their successors, prescribed thoughtfully, not universally
Back Secher, A, Jelsing, J, Baquero, et al (2014) 'The arcuate nucleus mediates GLP- 1RA liraglutide- dependent weight loss', Journal Clinical Investigation , 124, 447388
This risk has only been seen in animal studies, not in humans, but the medications still arent recommended if you or a family member has a history of this cancer or a condition called MEN 2
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