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Laboratory investigations have reported measurable changes in nitric oxide related signaling markers, endothelial migration assays, fibroblast gene expression profiles, and cytoskeletal reorganization markers in cell culture and animal models

Reid CA, Dixon DB, Takahashi M, Bliss TV, Fine A (2004)

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Waldman Published: Oct 2021 Expression and clinical significance of FOX04 in colorectal cancer The positive expression rate of FOXO4 protein in colorectal cancer tissues was 47.50%, which was significantly lower than that in matched noncancerous tissues (91.25%, P0.05)