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The most common adverse effects are gastrointestinal: nausea, vomiting, diarrhea, and constipation
The evidence is limited by small cohorts, heterogeneous study designs, and variable microbiome methodologies
GLP-1 is secreted as a pro-peptide that is then proteolytically cleaved into two active forms, (7-37) and (7-36)
This may result from metabolic adaptation, lifestyle factors, or dosing limitations
Additionally, tesamorelin side effects include joint pain, muscle aches, and peripheral edema
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