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The dual mechanism was confirmed at the cellular level, and the fragment showed no cross-reactivity with the growth hormone receptor (Ng & Borstein, 2003)
[102] Regular monitoring of liver function may be appropriate for patients receiving prolonged ondansetron therapy or those with risk factors for hepatic dysfunction
Consider earlier administration (3+ hours before bed) to allow cortisol-modulating effects to establish before sleep pressure builds
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Annual Review of Physiology , 73 , 413435
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