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Mutations in INK4A/p16 (90%) appear in PanIN-2, whereas Tp53 (85%) and SMAD4 (55%) mutations are found in PanIN-3
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10.1038/s41386-018-0010-3 26 HernandezN
PMID: 4 CuiPLiDShiLYanHLiTLiuCet al
REDEFINE 2 was a double-blind, randomized, placebo-controlled 68-week efficacy and safety phase 3 trial of once-weekly CagriSema versus placebo in 1,206 adults with type 2 diabetes and either obesity or overweight
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