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Carnitine levels are reduced in patients suffering Gram-negative sepsis and urinary loss of carnitine is proportional to the degree of injury [96]
However, the relevance of these findings to humans remains uncertain, as human thyroid C-cells have much lower expression of GLP-1 receptors compared to rodents
Patients experiencing significant side effects or concerns about their current semaglutide dose should take a systematic approach rather than self-adjusting their medication
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