While semaglutide is not a thyroid treatment, the metabolic shifts it triggers can have a significant "knock-on" effect on how your thyroid functions and how your medication is absorbed
Mounjaro slows gastric emptying and can cause gastrointestinal side effects such as nausea, vomiting, and reduced appetite
Trials that have examined efficacy of GLP-1RA therapies include Evaluation of Lixisenatide in Acute Coronary Syndrome [ELIXA] trial, 47 Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results [LEADER] trial, 6 Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes [SUSTAIN-6], 49 oral administration of semaglutide in the Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes [PIONEER-6], 50 once-weekly exenatide in the Exenatide Study of Cardiovascular Event Lowering [EXSCEL] trial, 51 albiglutide in the Harmony Outcomes trial, 52 and dulaglutide in the Researching Cardiovascular Events With a Weekly Incretin in Diabetes [REWIND] trial, 53 among others
doi: 10.1016/j.foodres.2024.114000 69
At the 1mg weekly dose, participants averaged 8.7% weight loss