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Results from randomized controlled trials and meta-analyses indicate that probiotic supplementation can significantly improve glucose and lipid metabolism, alleviate renal function impairment, and reduce inflammation and oxidative stress levels in DKD patients ( This review aims to systematically elucidate the central hub role of the gut microbiota-enterohepatic axis in dietary nutrient metabolism, with emphasis on exploring the association mechanisms between gut microbiota-mediated amino acid metabolism and DKD, and reviewing research progress on natural bioactive compounds targeting the gut microbiota-enterohepatic axis for DKD intervention

DHODH, in parallel with GPX4, suppresses mitochondrial lipid peroxidation by reducing CoQ to CoQH 2

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Th1 cells can produce interferon- (IFN- ) which inhibits the proliferation and activity of Th2 cells

For molecular analysis, immunofluorescence, and immunohistochemistry techniques were extensively used on human testis, mouse testis, and TM3 cells to visualize the expression and subcellular localization of key proteins