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[11] Severe constipation, abdominal distension, or inability to pass gas may indicate ileus or intestinal obstruction and requires urgent medical attention

Trial design: 751 adults with obesity (BMI 30, or 27 with at least one comorbidity) No type 2 diabetes 72-week follow-up Tirzepatide 10mg or 15mg vs Semaglutide 2.4mg Results at 72 weeks: When looking at tirzepatide weight loss results from SURMOUNT-5 alongside semaglutide weight loss results from the STEP trials, the gap is consistent and statistically significant across every subgroup sex, age, baseline BMI, and presence of metabolic comorbidities

Environmental Conditions : Exposure to high temperatures, moisture, and light can accelerate degradation

Although leptin suppresses the appetite when slightly raised, it seems to have the opposite effect when it gets too high

What Factors Affect How Fast Retatrutide Works