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This is because higher doses increase the medications effects in the body
Jastreboff AM, Kaplan LM, Fras JP, Wu Q, Du Y, Gurbuz S, Coskun T, Haupt A, Milicevic Z, Hartman ML (2023) Triple-hormone-receptor agonist retatrutide for obesity a phase 2 trial
GLP-1 medications make this weight loss significantly easier and more predictable than diet alone
Lack of Improvement Over Time Side effects may sometimes stay the same or even worsen as treatment continues
Together, these mechanisms explain how one peptide can address tendons, muscles, gut lining, nerves, and skin
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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