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Symptoms of too little thyroid hormones (hypothyroidism) include: Weight gain Trouble tolerating cold Constipation Fatigue or excessive tiredness Joint pain Muscle aches or pain Dry skin Thinning hair Slowed heart rate Heavy menstrual cycles Irregular menstrual cycles Feeling depressed more often than usual Symptoms of too much thyroid hormone (hyperthyroidism) are: Weight loss combined with eating more than usual Irregular, fast heartbeat Shaky hands Muscle weakness Trouble sleeping Fatigue Irritability Feeling anxious more often than usual Trouble adjusting to warm weather Too many bowel movements A goiter, which is an enlargement of the neck Weight loss is a main impact of GLP-1 medications, which may make it difficult to tell when a decrease on the scale stems from the weight loss medication or disruptions to the thyroid hormones in the body

Patients can expect comparable metabolic effects and weight reduction outcomes when using either formulation at equivalent doses

As shown in Figure 4, there are 11 enzymes relevant to glycolysis/gluconeogenesis upregulated in this dataset, including phosphofructokinase, aldolase, glyceraldehyde-3-phosphate dehydrogenase, phosphoglycerate kinase, enolase, and pyruvate kinase