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Seizures Bupropion, a component of CONTRAVE, can cause seizures
Its effects are temporary, usually lasting three to four months
Both medications share similar gastrointestinal side effects: nausea, diarrhea, vomiting, and decreased appetite
The STEP-4 trial (Rubino et al., JAMA , 2021) studied this directly: patients who reached goal weight on 2.4 mg were randomized to continue 2.4 mg vs switch to placebo
As expected, addition of CCL1 in the assay led to a dose-dependent increase in intracellular calcium, whereas addition of mAb1 alone did not change calcium levels, indicating a lack of mAb1 agonistic activity (Fig
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