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Firstly, hyperglycemia promotes local ANG II production in cardiomyocytes stimulating intracellular chymase and/or internalized prorenin, leading to diabetic cardiomyopathy

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Moreover, IGF-IR phosphorylation is elevated in breast cancer cells resistant to the p110 isoform-selective inhibitor BYL719, making the BYL719-resistant cells sensitive to IGF-IR inhibition [126]

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Autophagy 11, 1636 (2015), Application(s): WB, Abstract Full Text HER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interaction: H.J

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Cell supernatant was collected from each group, and the levels of IL-1, IL-6, TNF-, IL-8, and IL-10 were determined by ELISA

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