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93 % of patients achieved more than 10% weight loss compared to 9% on lifestyle changes alone 83% of patients achieved more than 15% weight loss compared to 2% on lifestyle changes alone
A real-world study and meta-analysis of observational studies
"If you're not as influenced by that, it becomes easier." In her 2025 book, "The Ozempic Revolution," Dr
This is when the body becomes less responsive to the peptide over time
Cardiovascular Outcomes# EXSCEL Trial (Exenatide)# The EXSCEL trial (Holman et al., NEJM 2017) enrolled 14,752 patients with type 2 diabetes (73.1% with prior cardiovascular disease) and followed them for a median of 3.2 years: Primary MACE endpoint : HR 0.91 (95% CI 0.83-1.00), p=0.06 for superiority Met non-inferiority but narrowly missed superiority (p=0.06) All-cause mortality was reduced by 14% (HR 0.86, p=0.016) in a secondary analysis EXSCEL confirmed cardiovascular safety but did not prove cardiovascular benefit -- a critical distinction
