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Compared to placebo, treatment with dipeptidyl peptidase-4 inhibitors (DPP4is) demonstrated non-inferiority for major adverse cardiac outcomes 3,4,5,6
Peptides make up proteins, some act as hormones
Verdict at a Glance Orforglipron represents a potential paradigm shift as the first oral non-peptide GLP-1 agonist without fasting restrictions, and it demonstrated superiority over oral semaglutide in the head-to-head ACHIEVE-3 trial for both HbA1c and weight loss
In addition to levodopa, DA receptor agonistssuch as pramipexole, ropinirole, and rotigotinecan also be utilized in the treatment of PD, particularly for early-stage patients or in conjunction with levodopa to delay the onset of motor complications (Herz et al., 2015)
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