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Because any excess is passed out in the urine rather than stored, there is no meaningful overdose risk, and serious reactions are rare
Previous studies have shown that OPZ requires metabolite bioactivation both to display potent schistosomicidal activity and inhibition of the GSSG reduction activity [58]
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S2CID 39628211
Do not exceed 2ml per injection without prescriber guidance doses above this threshold show no additional methylation benefit
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