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The UK CPRD data were linked to the Hospital Episode Statistics Admitted Patient Care (HES APC) and the Office for National Statistics (ONS) databases, but the linkage was available only in a subset of individuals
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"By hitting four different hormone receptors at the same time, we hope to improve the chances of averaging out such variation toward the goal of achieving greater and more consistent overall effectiveness." "A second issue is that patients tend to regain weight after discontinuing currently available GLP-1 related drugs," said Beinborn, who notes that lifestyle changes should ideally be a complement to medication treatment
While existing peptide-based therapies like semaglutide and tirzepatide have reshaped treatment, many patients still face incomplete results or intolerable side effects
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