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Liver Physiol

Improved insulin sensitivity: By modulating nicotinamide metabolism and influencing NNMT, the compound may reduce insulin resistance, thereby promoting better glucose management

Retatrutide is an investigational triple agonist targeting GLP-1, GIP, and glucagon receptors, currently unapproved by the MHRA, EMA, or FDA for routine clinical use

Animal studies suggest that it reduces NNMT activity, leading to better NAD+ retention, improved metabolic efficiency, and reduced fat mass

(PUBMED: Reference #1, Reference #2, Reference #3) B12 is added to alleviate the nauseous side effects that Tirzepatide can have on some patients