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Seiwerth S, Milavic M, Vukojevic J, Gojkovic S, Krezic I, Vuletic LB, et al

In fact, researchers have a name for the fat-to-lean-mass loss ratio that shows up across virtually every serious weight loss method: the quarter fat-free mass rule. It refers to the consistent finding that roughly 25% of weight lost during a significant calorie deficit comes from lean tissue, regardless of how that deficit was created

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Euglycemic diabetic ketoacidosis is another concern that may delay initiation or result in early discontinuation of SGLT2i therapy [4, 19]