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Spaulding and Yan, 2022)
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One randomized study that tested the effects of cold gloves and boots in 135 patients receiving carboplatin, docetaxel, or paclitaxel for breast cancer reported significantly less cold sensitivity, hand and foot numbness, and hand tingling in the cryotherapy group compared with the control group (Xu 2023)
Key findings Within six months of starting GLP-1 therapy, the rate of hypotensive events increased from 8.7% to 10.2% The increased risk remained significant at 12 months, with hypotensive events rising from 13.6% to 14.3% Adults age 65 and older accounted for 53% of hypotensive events despite representing 37% of the study population Patients with Type 2 diabetes made up 75% of those experiencing hypotensive episodes but only 63% of the overall cohort In secondary analyses, the scientists found that weight loss alone did not explain the increased risk, suggesting other mechanisms of action may be at play Below is a Q&A with study senior author Dr
Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel
